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KMID : 0605719980040010096
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Journal of the Korean Society of Biological Therapies in Psychiatry
1998 Volume.4 No. 1 p.96 ~ p.102
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New anticonvulsants and calcium channel blockers in treaatment-refractory bipiolar disorders
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1/2김영훈/12Young Hoon Kim
1/2이정구/1/2이상경/12Jung Goo Rhee/12Sang Kyeong Lee
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Abstract
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Most psychiatrists are familiar with the traditional anticonvulsants, carbamazepin and
valproic acid, in the treatment of the patients with bipolar disorders. Lamotrigine, a new
anticonvulsant, may have antidepressant and mood-stabilizing effects probably by
inhibition of pathological glutamate release on the presynaptic membrane, especially in
the treatment-refractory bipola disorders. Treating depression in bipolar disorder can be
difficult because of the limited antibepressant effects of the standard mood stabilizers
and the tendency of antidepressants to induce mania or decrease cycle length.
Lamotrigine, a drug that has both mood stabilizing and antidepreasant effects, would
have an important role in the treatment of refractory biploar disorders. The efficacy of
verapamil in the treatment of mania has been examined in several small open trials and
at least 7 double-blind trials, and that of nimodipine in a double-blind trial. Although
preliminary data suggest that verapamil may have antimanic or mood-stabilizing
properties, any conclusion about the efficacy of verapamil in the treatment of the
lithiun-refractory or rapid cycling bipolar patients could not be drawn till now.
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